According to a 2008 study, it gives similar results to the classic combo of Vitamin C + Vitamin E + Ferulic Acid: A mineral tinted fluid, this daily sunscreen is suitable for all skin types and instantly helps improve the appearance of uneven skin tone while protecting the skin from further discoloration and damage. Featuring micro-fine zinc oxide (Z-Cote®) and titanium dioxide to provide broad spectrum protection against UVA/UVB rays, this ultra-sheer, non-irritating formula is infused with artemia salina to enhance the skin’s natural defenses against UV- and heat-induced stress, plus translucent color spheres that help even out skin tone and boost skin’s radiance upon application. With a paraben- and fragrance-free, non-comedogenic formula that’s ideal for all skin types (including sensitive), this lightweight, water-resistant fluid provides a touch of coverage and leaves skin with a soft, radiant finish as well as no white cast. For evening use: Retinol 0.3, 0.5 or 1.0 The crosstalk between AMPK, Nrf2, and SIRT1 pathways in the anti-inflammatory effect of phloretin. The activation of AMPK and SIRT1 are closely related in the regulation of metabolism and pathologies such as oxidative stress and inflammation. Activation of AMPK by phloretin via its phosphorylation as well as increased expression of SERT1 have been associated with its anti-inflammatory effect and modulation of lipid metabolism such as inhibition of lipid accumulation. This activity was further shown to be related to the induction of Nrf2 that suppresses both the oxidative stress and inflammatory pathways induced by a variety of agents including LPS. Increased SERT3 activity by phloretin is also reported. The red line shows the inhibitory response.

I still prefer Vitamin C + Vitamin E + Ferulic acid to the Phloretin version, just because it’s been more researched during the years. But Phloretin is very promising, too. KEY INGREDIENTS & BENEFITS: Alpha Tocopherol (neutralizes free radicals and replenishes skin lipids), Ferulic Acid (neutralizes free radicals and enhances the antioxidant benefits of vitamins C and E) SkinCeuticals Phloretin CF contains three potent antioxidants that can help to protect your skin from free radical damage while also promoting a more youthful complexion. Irritation:High concentrations (%15) of L-Ascorbic Acid – especially at the low pH (below 3) it needs to work its magic – can irritate skin, especially if it’s sensitive. Phloretin CF uses 10%, a concentration that’s sensitive skin-friendly. Due to air and light exposure, vitamin C products can darken after opening. The formula will remain effective.Daily use of a properly formulated pure vitamin C antioxidant neutralizes free radicals and helps prevent environmental damage. Patented Phloretin CF is a high-performance antioxidant serum with 10% pure vitamin C, 2% phloretin, and 0.5% ferulic acid demonstrated to visibly improve discoloration by 19% and fine lines by 24% for a more even, radiant skin tone.)

No, Skinceuticals isn’t cruelty-free. They may test on animals or outsource the process. Their parent company, L’Oreal, surely does. Price & Availability One of the main benefits of ascorbic acid is its potent antioxidant activity. Ascorbic acid donates electrons to neutralize free radicals from environmental factors such as UVA/UVB radiation, infrared radiation (IRA), and ozone pollution (O3). This is important because the harmful effects of free radicals occur as direct chemical alterations of the cellular DNA, the cell membrane, and cellular proteins, including collagen. Damaged collagen manifests as signs of premature skin aging, including wrinkles, lines, and sagging skin. By protecting collagen and other skin components, ascorbic acid helps to prevent signs of aging. This is one way that SkinCeuticals Phloretin CF provides advanced environmental protection. Groundbreaking for its day, it has now become the gold standard for Vitamin C serums and inspired a long string of dupes (and lawsuits). Now they’re bringing another innovation, 15% L-Ascorbic Acid (Vitamin C) + Ferulic Acid + Phloretin. Will it be as successful as its predecessor? Only time will tell. Key Ingredients In Skinceuticals Phloretin CF: What Makes It Work?

Should I use Phloretin CF or C E Ferulic?

One: it removes everything that’s not absolutely necessary, like fragrance and fancy plant extracts that look good in the marketing copy but do absolutely nothing for your skin. Alcohol Denat is one of the most misunderstood ingredients in skincare. Word on the street is that it’s terribly drying and irritating. Green: It’s effective, proven to work, and helps the product do the best possible job for your skin. CE Ferulic is more hydrating, so it’s a better option for dry skin. It also has a less drying delivery system that makes it more suitable for sensitive skin types. Plus, the combination of Vitamin C + Vitamin E + ferulic acid has been around longer and is more studied than the combination of Vitamin C + Ferulic acid + Phloretin, so I’m more inclined to recommend the former. The hepatoprotective effect of phloretin has been demonstrated under various in vivo experimental models including overdose intake of acetaminophen [ 28], choline [ 93], D-galactosamine (D-GalN) [ 30], and arsenate [ 94]. These effects which are also shown in renal protection by toxic agents (e.g., by Singh et al. [ 94]) mostly demonstrated the antioxidant mechanism of therapeutic potential of phloretin. The focus herein is to highlight the inflammatory mechanisms of hepato- and renoprotective effects.

SkinCeuticals C E Ferulic Antioxidant Serum has received countless awards and accolades (in addition to garnering a cult following) since its debut in 2005, but we don’t like to play favorites when it comes to the brand’s vitamin C topical antioxidant serums! C E Ferulic’s younger sibling, Phloretin CF Antioxidant Serum, has made a name for itself since its introduction in 2008, and this vitamin C serum offers all the advanced antioxidant protection SkinCeuticals is known for while providing a unique set of benefits. Should I use Phloretin CF or C E Ferulic? NOTE: The colours indicate the effectiveness of an ingredient. It is ILLEGAL to put toxic and harmful ingredients in skincare products. SkinCeuticals Phloretin CF is an advanced daytime antioxidant serum that provides superior environmental protection that is a pigment regulator helping to reduce dullness and discolouration of the skin, it retextures and evens skin tone for a brighter more radiant complexion. Suitable for normal, combination skin with ageing and hyperpigmentation.Related: The Truth About Alcohol-Free Skincare: What Does It Really Mean? (Hint: It’s Not What You Think)